FISV 2016
XIV Congress

  Rome, Italy • 20-23 September 2016  


Programme [19/9/2016]

Programme & Abstracts book

Sapienza University map

  • Tuesday, 20 September




    Opening & Welcome (Aula Magna)

    Eugenio Gaudio (Rettore, Sapienza University of Rome)

    Felice Cervone (FISV President)

    Commemoration of Paolo Bianco by Giulio Cossu and Guido Tarone by Ruggero Pardi


    Plenary Lecture (Aula Magna)

    Chair: Felice Cervone (FISV President)

    Gerry Melino (Rome and Leicester, UK)
    The P53 Family in cancer biology


    Free time for lunch


    Plenary Lecture (Aula Magna)

    Chair: Rodolfo Negri (Rome)

    Ernesto Di Mauro (Viterbo)
    On the spontaneous generation of ribozymes and of life


    Plenary Symposium (Aula Magna)
    Cancer Stem Cells

    Chairs: Gennaro Ciliberto (Naples), Ruggero Pardi (Milan)

    Dominique Bonnet (London, UK)
    Remodelling the Hematopoietic Stem Cell Niche by Acute Myeloid Leukemic Cells

    Riccardo Fodde (Rotterdam, Netherlands)
    Intestinal Stem Cells in Homeostasis, Inflammation and Cancer: a Matter of Niche

    Pier Paolo Di Fiore (Milan)
    The Numb: p53 axis connect asymmetric cell division and tumor suppression in mammary stem cells

    Stefano Piccolo (Padua)
    YAP/TAZ in stem cells and tissue regeneration


    Coffee break


    Plenary Symposium (Aula Magna)
    CRISPR/CAS: from a prokaryotic immune system to a powerful tool for biomedical and agricultural research

    Chairs: Bianca Colonna (Rome), Michele Morgante (Udine)

    Rotem Sorek (Rehovot, Israel)
    The immune system of bacteria: CRISPR and beyond

    Wolfgang Wurst (Neuherberg, Germany)
    CRISPR/Cas9 Technology: Universal Tool for Functional Genome Annotation

    Holger Puchta (Karlsruhe, Germany)
    Double-strand break induced genome engineering in plants


    Round Table (Montalenti Hall)
    The odd couple: Biology and Physics working together

    Chair: Silvia Bencivelli (RadioRaiTre, Master di comunicazione scientifica della Sapienza Università di Roma)
    Giulio Giorello (Milano)
    Riccardo Cortese (Okairòs, Rome)
    Massimiliano Viale (Rome)

  • Wednesday, 21 September


    Plenary Lecture (Aula Magna)

    Chair: Isabella Saggio (Rome)

    Roland Foisner (Vienna, Austria)
    Nuclear architecture and chromatin dynamics


    Coffee break


    Plenary Symposium (Aula Magna)
    Oxygen Sensing and Redox Signalling: common themes of aerobic life

    Chairs: Pierdomenico Perata (Pisa), Giulia De Lorenzo (Rome)

    Peter J. Ratcliffe (Oxford, UK)
    Sensing oxygen levels in animal cells by HIF hydroxylases

    Francesco Licausi (Pisa)
    When plants face oxygen limitations

    Stéphane D. Lemaire (Paris, France)
    Proteomics unravel an intricate redox network of 1000 proteins regulated by thioredoxin, glutathione and nitric oxide

    Paolo Trost (Bologna)
    How ROS-mediated glutathionylation may induce amyloid-like aggregation of plant glycolytic GAPDH


    UNIMED Scientifica – Short Talk (Aula Magna)

    Giulio Caracciolo (Rome)
    Transfection efficiency boost in hard-to-transfect cells by MENS reagents


    Free time for lunch and Posters viewing (Session I)


    Short talks by participants (Session I):

    IMPORTANT NOTE The session Environmental and Molecular Mutagenesis has been merged with the session DNA replication, Repair and Recombination

    • 14:30-16:00  •  Montalenti Hall

      Environmental Microbiology and Biotechnology

      Chairs: Daniela Uccelletti, Michele Maria Bianchi, Annamaria Bevivino

      Andrea Franzetti (Milan)
      Light promotes the growth of heterotrophic bacteria and pollutant biodegradation on glacier surface

      Alessandro Giuffrè (Rome)
      How bacteria can respire O2 in sulfide-rich environments: a new role for bd-type terminal oxidases

      Nicoletta La Rocca (Padua)
      Photosynthesis on extrasolar planets: state of art and preliminary results of a pioneering experiment

      Rachele Isticato (Naples)
      Localization of a red fluorescence protein adsorbed on wild type and mutant spores of Bacillus subtilis

      Francesco Restivo (Parma)
      In vitro evaluation of the activity of thiosemicarbazone derivatives against mycotoxigenic fungi affecting cereals

      Elisa Scioscia (Benevento)
      Antimicrobial activity of unifloral honeys extracts from Campania against pathogenic bacteria and fungi

      16:00-17:30  •  Montalenti Hall

      Genetics of Microorganisms

      Chairs: Alessandra Polissi, Gianni Prosseda

      Federica Briani (Milan)
      Temperature-dependent regulation of the lpxT gene in Escherichia coli and Pseudomonas aeruginosa

      Giulia Giallonardi (Rome)
      Alkyl-quinolone-dependent quorum sensing controls prophage activation, autolysis and antibiotic resistance in Pseudomonas aeruginosa biofilm

      Sarah Hijazi (Rome)
      Gallium-protoporphyrin IX uptake pathways in Pseudomonas aeruginosa and growth inhibition by cytochromes targeting

      Beatrice Silvia Orena (Pavia)
      Multitargeting antitubercular compounds: a new precious tool in multidrug resistance age

      Anna Maria Puglia (Palermo)
      The small protein SCO2038 modulates tryptophan biosynthesis and morpho-physiological differentiation in Streptomyces coelicolor

    • 14:30-16:00  •  Giacomini Hall

      Genomics, Proteomics and Systems Biology

      Chairs: Lilia Alberghina, Diego Di Bernardo

      Emanuele Bosi (Florence)
      Comparative genome-scale modelling of Staphylococcus aureus strains identifies strain-specific metabolic capabilities linked to pathogenicity

      Alexey Kolodkin (Belvaux, Luxembourg)
      Dynamic networks dealing with oxidative stress: from design principles to personalised therapies for Parkinson’s disease

      Marco Montini (Florence)
      Using CRISPR/Cas9 to determine the order of specific events in a cellular system

      Marco Vanoni (Milan)
      Multi-level modeling of Metabolism, Growth and Cycle in Saccharomyces cerevisiae

      Domenico Raimondo (Rome)
      Computational design of short linear D-tripeptides as binding moieties for protein pockets

      16:00-17:30  •  Giacomini Hall

      Transcription Mechanisms and Networks

      Chairs: Paolo Vincenzo Pedone, Giorgio Dieci

      Flavia Bernardi (Rome)
      Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype

      Leonardo Gatticchi (Perugia)
      Intracellular trafficking of labelled BODIPY-FF-MAS reveals nuclear lipid droplets localization

      Ilaria Baglivo (Caserta)
      A new DNA target site for transciption factors from M. loti

      Susanna Ambrosio (Naples)
      LSD1 mediates MYCN control of epithelial-mesenchymal transition through silencing of metastatic suppressor NDRG1 gene

      Annapina Russo (Naples)
      5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-b-synthase in colon cancer cells lacking p53

      Stefano Amente (Naples)
      High-resolution genome profiles of 8-oxodeoxyguanine, gH2AX and NBS1 reveals their co-association at transcribed long genes

    • 14:30-16:00  •  Blue Hall 2

      Chromosome Biology, Cell Division and Cell Cycle

      Chairs: Matteo Barberis, Patrizia Lavia

      Deborah Pajalunga (Rome)
      A dysregulated dNTP pool hinders DNA replication in cell cycle-reactivated terminally differentiated cells

      Marco De Vitis (Rome)
      Alternative lengthening of telomere (ALT) implicated in telomere length modulation induced by x-rays in human primary fibroblasts

      Giusj Monia Pugliese (Rome)
      CK2 phosphorylation of MUS81 regulates its activation for proper resolution of dna intermediates in mitosis

      Veronica Ferrucci (Naples)
      Microcephaly with neurodevelopmental impairment shows microtubule assembly defects with h-prune mutations during mitosis

      Elena Paccosi (Viterbo)
      CSA and CSB proteins localize to the midbody during cytokinesis and regulate abscission through PRC1 degradation

      16:00-17:30  •  Blue Hall 2

      DNA replication, Repair and Recombination

      Chairs: Marco Muzi Falconi, Antonio Antoccia

      Ennio Prosperi (Pavia)
      DNA repair defects in Rubinstein-Taybi syndrome caused by low acetylation levels of base excision repair factors

      Cinzia Caggiano (Rome)
      Balancing DNA double strand break repair pathway choice as trigger for testicular germ cell tumors acquired-resistance to cysplatin

      Francesco Cucco (Pisa)
      Separase prevents genome instability by controlling fork replication speed

      Eva Malacaria (Rome)
      Inaccurate GEN1 DSBs formation promote genome instability in FA-P cells

      Francesca Ripanti (Rome)
      Measuring oxidized DNA and RNA precursors by Micro-Raman spectroscopy

      Elisa Coluzzi (Rome)
      Effects of oxidative stress on telomere structure and telomeric epigenetic modifications

    • 14:30-16:00  •  Blue Hall 3

      Epigenetics and Epigenetic Therapies

      Chairs: Carlo Presutti, Michele Milella

      Andrea Iannello (Orbassano, TO)
      Genomic regulatory regions role in Th17 and Treg cells balance during pregnancy of multiple sclerosis patients

      Alice Mazzagatti (Pavia)
      The epigenetic landscape of equid centromeres: a cytogenetic approach

      Alberto Passi (Varese)
      Epigenetic control of hyaluronan synthases

      Simone Pippa (Rome)
      Use of JARID histone demethylases inhibitors to enlighten the biological role of these enzymes in yeast and mammalian cells with focus on transcriptional regulation

      Angela Sparago (Caserta)
      Unraveling the role of NAP1L1 into the chromatin of mammals

      16:00-17:30  •  Blue Hall 3

      Non-coding RNA

      Chairs: Alessandro Fatica, Francesco Fazi

      Cecilia Battistelli (Rome)
      The lncRNA HOTAIR links the repressor Snail to epigenetic modifications of specific genomic sites in Epithelial-to-Mesenchymal Transition

      Pietro Laneve (Rome)
      Linc-NeD125 establishes a ceRNA network in Group 4 Medulloblastoma

      Mariangela Morlando (Rome)
      Newly identified long non-coding RNAs promote proliferation and differentiation of murine myoblasts

      Paola Infante (Rome)
      Serum miRNAs as novel biomarkers in spinal muscle atrophy

    • 14:30-16:00  •  Blue Hall 4

      Oncogenes and Tumor suppressors

      Chairs: Silvia Soddu, Giulia Piaggio

      Manuela Caputo (Viterbo)
      CSB ablation induced apoptosis is mediated by increased endoplasmic reticulum stress response

      Francesca Bufalieri (Rome)
      ERAP1 is a novel drug target in the oncogenic Hedgehog signaling pathway

      Andrea Camperi (Turin)
      Role of STAT3 in the cross-talk between cancer associated fibroblasts and cancer cells

      Simone Di Giacomo (Bologna)
      MYC-mediated cell competition as an evolutionary trait of cancer

      Fabiana Ferrara (Rome)
      Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity

    • 14:30-16:00  •  Blue Hall 1

      Plant Metabolism and Environmental Stress

      Chairs: Concetta De Pinto, Maurizio Badiani

      Olivia Demurtas (Rome)
      Crocin biosynthesis in saffron stigmas: a tale of three compartments

      Michela Zottini (Padua)
      The mitochondrial nucleoid associated WHIRLY2 affects morphology and dynamics of mitochondria

      Francesca Sparla (Bologna)
      β-amylase-1-dependent starch degradation in mesophyll cells releases carbon skeletons required for the production of proline

      Francesca Secchi (Grugliasco, TO)
      Acidification of xylem sap pH observed in woody plants provides apoplastic environment for facilitating recovery from water stress

      Namrata Mancuso (Rome)
      Comparative analysis of the role of the different Arabidopsis polyamine oxidases in plant defense responses to environmental stresses

      16:00-17:30  •  Blue Hall 1

      Plant Nutrition

      Chairs: Irene Murgia, Stefania Astolfi

      Gianpiero Vigani (Milan)
      Keynote Lecture: Plant adaptation mechanism to Fe deficiency: the role of metabolism

      Laura Zanin (Udine)
      The urease inhibitor N-(N-butyl) thiophosphoric triamide (NBPT) affects urea acquisition and metabolism in maize seedlings

      Silvia Perotto (Turin)
      Fungal and plant gene expression in the Tulasnella calospora - Serapias vomeracea association provides cues on the N pathways in orchid mycorrhiza

      Davide Sega (Verona)
      FePO4 nanoparticles ad fertilizers: synthesis and evaluation of their effect on plants

      Eleonora Cominelli (Milan)
      Isolation and characterization of a new low phytic acid mutant in the common bean PvMRP1 gene and study of PvMRPs promoters in two different plant systems


    Coffee break


    Societies' time

    AGI (Giacomini Hall)

    18:00 Premio AGI "Ferruccio Ritossa" 2016 e presentazione del lavoro premiato
    18:20 Premio Dottorato AGI/Zanichelli 2016 e presentazione del lavoro premiato
    18:40 Assemblea dei Soci AGI

    SIB (Hall A, Building CUO10)

    Assemblea dei Soci
    Consegna Premio SIB
    Consegna Premio Heritage
    Votazioni per il parziale rinnovo del CD

    SIBV (Blue Hall 2)

    Premio Assunta Baccarini Melandri
    Assemblea dei soci

    SIMA (Blue Hall 3)

    Assemblea dei soci

    SIMGBM (Montalenti Hall)

    Premiazione Premi 2016

    • Premio Franco Tatò
    • Premio Mario Campa
    • Premio NAICONS
    Assemblea dei soci


    Social dinner on the Tiber (Baja - Lungotevere Arnaldo da Brescia)

  • Thursday, 22 September


    Plenary Symposium (Aula Magna)
    Systems Biology: From Genetic Networks to Organismal Functions

    Chairs: Duccio Cavalieri (Florence), Matteo Barberis (Amsterdam, Netherlands)

    Brenda Andrews (Toronto, ON, Canada)
    From phenotypes to pathways: global exploration of cellular networks and pathways using systematic yeast genetics and cell biology

    Jens Nielsen (Göteborg, Sweden)
    Systems Biology of Yeast Metabolism

    Diego Di Bernardo (Naples)
    Robustness and evolvability of gene networks, role ofmiRNAs and protein stability in rewiring gene expression

    Matteo Barberis (Amsterdam, Netherlands)
    The Multiplex Phase Interlocker - A novel and robust molecular design synchronizing transcriptional regulation of cell cycle dynamics


    Coffee break


    Parallel Symposia

    1. The (recent) evolution of human evolution (Montalenti Hall)

    Chairs: Giovanni Destro Bisol (Rome), Luigi Capasso (Chieti)

    Andrea Manica (Cambridge, UK)
    The role of climate in shaping human genetic variation

    Guido Barbujani (Ferrara)
    Human evolutionary genomics: Out of Africa and beyond

    Claudio Tuniz (Trieste)
    Methodological and conceptual advancements in human evolution studies

    Antonio Rosas González (Madrid, Spain)
    Recent discoveries and classic models: Neandertals and Outs of Africa

    2. From Reverse- to Structural-Vaccinology and beyond. Current challenges against infectious diseases (Aula Magna)

    Chairs: Martino Bolognesi (Milan), Guido Grandi (Trento)

    Steve Michell (Devon, UK)
    New vaccines against Clostridium difficile based on surface proteins

    Giorgio Colombo (Milan)
    Antigen and epitope design: what can computational biology tell us?

    Louise Gourlay (Milan)
    A structural vaccinology approach to melioidosis vaccine component development

    Guido Grandi (Trento)
    Vaccinology: the art of putting together the right ingredients

    3. Nitrogen: Nutritious and Noxious (Blue Hall 1)

    Chairs: Francesca Sparvoli (Milan), Roberto Pinton (Udine)

    Christoph Müller (Giessen, Germany)
    Understanding the nitrogen cycle in a changing world

    Zeno Varanini (Verona)
    The regulation of nitrogen uptake by plants in the context of root-soil relationships: which form and which control?

    Steven Spoel (Edinburgh, UK)
    Signalling with nitrogen: reversible S-nitrosothiol protein modifications

    Roberto Tuberosa (Bologna)
    Leveraging the root QTLome to enhance nitrogen-use efficiency in cereals


    MERCK – Short Talk (Aula Magna)

    Silvia Di Meglio (Milan)
    Genome Editing with CRISPR Technology


    Free time for lunch and Posters viewing (Session II)


    Short talks by participants (Session II):

    • 15:30-17:00  •  Blue Hall 2

      Cellular Stress, Apoptosis and Autophagy

      Chairs: Gerry Melino, Roberto Amendola

      Federico Bianchi (Turin)
      Citron Kinase deficiency leads to p53-dependent microcephaly and DNA damage accumulation indipendently of its cytokinetic function

      Sara Beji (Rome)
      The nucleolar protein Nucleophosmin is rapidly secreted by human cardiac stromal cells in response to genotoxic stress: implications in miRNA mediated cell/cell communication

      Cristina Mazzoni (Rome)
      RNA oxidation and ageing in mRNA degradation mutants of S. cerevisiae

      Annapina Russo (Naples)
      rpL3 mediates the cell response to nucleolar stress induced by Act D in p53 null cancer cells

      Marialuisa Piccolo (Naples)
      In vitro bioactivity of ruthenium-based multifunctional nucleolipidic liposomes: new promising agents for cancer therapy

      17:00-18:30  •  Blue Hall 2

      Protein Synthesis, Degradation and Homeostasis

      Chairs: Antonio Feliciello, Marzia Perluigi

      Loredano Pollegioni (Varese)
      Schizophrenia susceptibility genes: on the characterization of two variants of human pLG72

      Vittorio Bellotti (Pavia)
      A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

      Giulia Tedeschi (Milan)
      The double life of a disordered protein between solubility and aggregation propensity

      Antonio Feliciello (Naples)
      Integration of cAMP and the ubiquitin system at primary cilium

    • 15:30-17:00  •  Blue Hall 3

      Development, Differentiation and Aging

      Chairs: Giorgio Camilloni, Graziella Messina

      Chiara Gabellini (Pisa)
      Modeling human intellectual disability and autism: role of the chromatin regulator setd5 during zebrafish brain development

      Catherine Labbaye (Rome)
      miR-143/β-DB/synapsin I, new players in Early Stages of Neural Differentiation

      Mattia la Torre (Rome)
      AKTIP (Ft1), a protein that interacts with lamins, is required for telomere maintenance and mouse development

      Duccio Cavalieri (Sesto Fiorentino, FI)
      The human fungal mycobiome composition reflects age, gender, immune function and diet

      Valentina Mularoni (Rome)
      Regulation of human testicular steroidogenesis during aging

      17:00-18:30  •  Blue Hall 3

      Stem Cells, iPS, Cancer Stem Cells

      Chairs: Caterina Missero, Alessandro Rosa

      Alessia Noto (Rome)
      Stearoyl-CoA-Desaturase (SCD1) regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

      Ilio Vitale (Rome)
      CHK1 as a target to kill colorectal cancer stem cells

      Bruna Corradetti (Ancona)
      Biomimetic coatings to improve MSC homing toward the site of inflammation

      Riccardo De Santis (Rome)
      Induced Pluripotent Stem Cells (iPSCs) as a disease model system to identify altered pathways in Amyotrophic Lateral Sclerosis

      Eris Bidollari (Rome)
      Induced Pluripotent Stem Cells (iPSC) as a model of Huntington disease

    • 15:30-17:00  •  Montalenti Hall

      Metabolism and its Regulation in Health and Diseases

      Chairs: Mauro Magnani, Francesco Paolo Mancini

      Simona Barbato (Bologna)
      Modulation of bioenergetics by the F1F0-ATPase inhibitor protein in cancer cells

      Sara Biagiotti (Urbino)
      Dexamethasone effects in Ataxia Telangiectasia cell metabolism

      Chiara Damiani (Milan)
      Unraveling the design principles of cancer metabolic rewiring with constraint-based modeling

      Alessio Paone (Rome)
      Toll like receptors: linking inflammation to carcinogenesis

      Matteo Audano (Milan)
      Zc3h10 controls mitochondriogenesis and differentiation in skeletal muscle

      Alberto Zullo (Benevento)
      DNA methylation of sirtuin genes in nutrient-deprived cultured cells

      17:00-18:30  •  Montalenti Hall

      Nutrition Biochemistry

      Chairs: Silvana Hrelia, Francesco Bonomi

      Emanuela Leoncini (Rimini)
      Evaluation of the potential protective effect on vascular endothelium exerted by the peptide nsLTP2 identified in wheat

      Emma De Fabiani (Milan)
      Strawberry tannins exhibit anti-inflammatory activities in vitro by inhibiting the NF-κB pathway and by other mechanisms

      Paola Coccetti (Milan)
      Methionine metabolism imbalance in AMPK-deficient yeast models

      Alberto Barbiroli (Milan)
      Polystyrene nanoparticles to mimic a complex matrix: functional and structural features of a hypoglycaemic lupin protein

      Laura De Gara (Rome)
      Protective effect of inulin on LPS-induced intestinal smooth muscle impairment: a redox and proteomic approach

    • 15:30-17:00  •  Giacomini Hall

      Human Genetics and Genomic Diversity

      Chairs: Davide Pettener, Antonio Torroni

      Vincenza Battaglia (Pavia)
      The worldwide spread of the tiger mosquito as revealed by mitogenome diversity

      Andrea Brunelli (Ferrara)
      Who likes to travel alone? Grammars and genes in the history of Old World migrations

      Nicole Grandi (Monserrato, CA)
      HERV-W presence and evolution within the primates lineage: characterization of the group in non-human primates and identification of highly related elements in New World Monkeys

      Viola Grugni (Pavia)
      The phylogeny of Y-chromosome haplogroup Q-L54: new insights on the first peopling of South America

      Ugo Perego (Pavia)
      Reconstructing the autosomal profile of Joseph Smith Jr, founder of Mormonism: a paternity application

      Marco Sazzini (Bologna)
      Evolutionary medicine insights from the depiction of the Italian genomic landscape

      17:00-18:30  •  Giacomini Hall


      Chairs: Guido Barbujani, Claudio Tuniz

      Marco Barucca (Ancona)
      Evolution of vitellogenin gene family in basal sarcopterygians

      Giorgio Binelli (Varese)
      Tropical rainforests that persisted: histories from the Quaternary in the Guiana shield

      Cristina Giuliani (Bologna)
      DNA methylation diversity in human populations

      René Marsano (Bari)
      The role of promoter in horizontal transposon transfer: the case of Bari transposons

      Francesca Tassi (Ferrara)
      Complete mitochondrial sequences from Mesolithic Sardinians suggest genetic discontinuity within the island

    • 15:30-17:00  •  Blue Hall 4


      Chairs: Andrea Mele, Francesco Laquaniti, Arianna Rinaldi

      Marzia Perluigi (Rome)
      Crosstalk between insulin and mTOR signaling in Down syndrome and Alzheimer disease

      Roberta Piovesana (Rome)
      Effects mediated by M2 muscarinic receptors activation in Schwann-like cells induced from adipose mesenchymal stem cells: implication in nerve regeneration

      Alessandra Maria Adelaide Chiotto (Turin)
      Neuronal cell autonomous defects in a mouse model of Down Syndrome: contribution of TTC3 gene

      Pamela Cappelletti (Varese)
      Amino acid substitutions in D-amino acid oxidase related to human pathologies

      Lionella Palego (Pisa)
      Peripheral biomarkers of oxidative stress in depressed elderly patients

      17:00-18:30  •  Blue Hall 4

      Cell Communication, Cell Adhesion and Membrane Trafficking

      Chairs: Fulvio Della Ragione, Mauro Maccarrone

      Andrea Magrì (Catania)
      Does SOD1 mediate the cellular communication between mitochondria and nucleus in stress condition?

      Simona Reina (Catania)
      Cysteine mutagenesis in VDAC3 reveals a functional role of these residues in the intracellular communication

      Lorenzo Depau (Siena)
      Tetra-branched peptide theranostics: preclinical development for cancer targeting

      Debora Bencivenga and Fulvio Della Ragione (Naples)
      Biochemical and functional characterization of cancer-associated p27Kip1 mutants

      Mauro Maccarrone (Rome)
      S-Palmitoylation modulates type 1 cannabinoid receptor localization, trafficking and biological activity

    • 15:30-17:00  •  Blue Hall 1

      Immunology and Host-Pathogen Interaction

      Chairs: Anna Teresa Palamara, Aldo Venuti

      Giovanni Bacci (Sesto Fiorentino, FI)
      Shotgun metagenomic analysis of sputum samples from cystic fibrosis patients revealed distinct metabolic modules and antibiotic resistance genes along with severe lung disease

      Carlotta De Filippo (Florence)
      Alteration of gut microbiota profiles in juvenile idiopathic arthritis. Associations with HLA-B27 status and disease activity

      Angela Arciello (Naples)
      Novel human antimicrobial peptides from ApoB are endowed with promising anti-inflammatory properties

      Alessandra di Masi (Rome)
      Human serum albumin acts as a self-defense protein towards Clostridium difficile infection

      Moira Giovannoni (Rome)
      Identification and analysis of candidate genes involved in the oligogalacturonide-induced responses in Arabidopsis thaliana

      17:00-18:30  •  Blue Hall 1

      Plant Development and Disease

      Chairs: Alma Balestrazzi, Franco Faoro

      Ilaria Fraudentali (Rome)
      The apoplastic copper amine oxidase AtCuAOβ plays a role in stomatal closure induced by wounding, jasmonate or Microbe Associated Molecular Patterns (MAMPS)

      Damiano Lironi (Rome)
      Role of lysin motif-containing receptor-like Kinase2 in Arabidopsis immunity

      Giovanni Mele (Monterotondo, RM)
      Meristem activity is controlled via extensive regulation of brassinosteroid pathway by class 1 homeobox transcription factors family

      Maurizio Trovato (Rome)
      Proline modulates root meristem size and root growth in Arabidopsis

      Ilaria Verrascina (Rome)
      Homeostasis of oligogalacturonides and their activity as Damage-Associated Molecular Patterns (DAMPs)

      Matthias Weiland (Bonn, Germany)
      The glutamate receptor AtGLR3.7 as a regulator of growth and development in Arabidopsis thaliana


    Plenary Lecture (Aula Magna)

    Chair: Tomas Morosinotto (Padua)

    Anna Moroni (Milan)
    Plant photoreceptors as a tool in neuroscience

  • Friday, 23 September


    Parallel Symposia

    1. Shaping the cancer genome: from pathways to mutational signatures (Aula Magna)

    Chairs: Margherita Bignami (Rome), Silvo Conticello (Florence)

    Ludmil Alexandrov (Los Alamos, NM, USA)
    Signatures of mutational processes in human cancer

    Angela Gallo (Rome)
    RNA Editing dynamically rewrites the cancer code

    Pietro Pichierri (Rome)
    Pathological replication fork recovery mechanisms and signature of genome instability in human cells

    Svend Petersen-Mahrt (Milan)
    Targeted genomic lesions - to ignore, to repair, to repair badly, or to mutate. Understanding DNA deaminase induced lesions and DNA repair choice

    2. Unfolding truth: making sense of intrinsically disordered proteins (Giacomini Hall)

    Chairs: Pier Luigi Martelli (Bologna), Andrea Mozzarelli (Parma)

    Peter Tompa (Brussel, Belgium)
    The tripartite degron model: the role of structural disorder in protein quality control

    Sonia Longhi (Marseille, France)
    Protein complementation and kinetics illuminate mechanisms of partner recognition by IDPs

    Stefano Gianni (Rome)
    Understanding the mechanisms of folding and binding of intrinsically disordered proteins

    Silvio Tosatto (Padua)
    Cataloguing and annotating flavours of intrinsic disorder in proteins with MobiDB

    3. Plant adaptation and phenotypic plasticity to climate change (Montalenti Hall)

    Chairs: Mario Pezzotti (Verona), Andrea Schubert (Turin)

    Christophe Maurel (Montpellier, France)
    Plant aquaporins as targets and players of cell signalling

    Andrea Nardini (Trieste)
    Climate change and forest decline: the physiology of tree mortality

    Maarten Koornneef (Wageningen, Netherlands)
    Exploring natural variation in Arabidopsis

    Silvia Dal Santo (Verona)
    Dissecting GxE interactions in grapevine through a transcriptomic approach


    Coffee break


    Plenary Symposium (Aula Magna)
    New roles and molecular pathophysiology of mitochondria

    Chairs: Paolo Sarti (Rome), Vito De Pinto (Catania)

    Andrea Rasola (Padua)
    Shutting your TRAP to kill tumors? The oncogenic role of the mitochondrial chaperone TRAP1

    Lorenzo Galluzzi (Paris, France)
    Mitochondrial control of stress responses and danger signalling

    Vito De Pinto (Catania)
    Mitochondrial VDAC isoforms: a bridge (and a target) between an oxidative and a reducing compartment

    Isabella Panfoli (Genoa)
    Pathophysiology of the extra-mitochondrial oxidative phosphorylation


    Free time for lunch



    The EMBO Keynote Lecture (Aula Magna)

    Chair: Gennaro Ciliberto (Naples)

    Titia Sixma (Amsterdam, Netherlands)
    Trapping transient states in DNA mismatch repair


    Congress closure

  • Posters

    When preparing your poster, please remember that its maximum size is 95 x 115 cm (width x height).

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...


    • Wednesday, 21 September • 12:45-14:30

      Topic 1 - Environmental Microbiology and Biotechnology

      Topic 2 - Genomics, Proteomics and Systems Biology

      Topic 3 - Chromosome Biology, Cell Division and Cell Cycle

      Topic 4 - Epigenetics and Epigenetic Therapies

      Topic 5 - Oncogenes and Tumor suppressors

      Topic 6 - Plant Metabolism and Environmental Stress

      Topic 7 - Genetics of Microorganisms

      Topic 8 - Transcription Mechanisms and Networks

      Topic 9 - DNA replication, Repair and Recombination

      Topic 10 - Non-coding RNA

      Topic 12 - Plant Nutrition

      P1.1 Khaled Farag A Abdelrhman (Florence)
      Contrasting effect of diet shift on the gut microbiota of two amphoipods species Orchestia montagui and Talitrus saltator

      P1.2 Loredana Baccigalupi (Naples)
      Lactobacillus gasseri SF1183 protects the intestinal epithelium and prevents colitis symptoms in vivo

      P1.3 Valerio Baldelli (Rome)
      Identification of FDA-approved compounds targeting the pqs quorum sensing system of Pseudomonas aeruginosa

      P1.4 Alessandra Bardi (Livorno)
      Fungal treatment for recalcitrant compounds removal
      In raw leachate and synthetic mixtures

      P1.5 Michele Bianchi (Rome)
      Environmental effects on the regulation of fatty acids biosynthesis in Kluyveromyces lactis

      P1.6 Gianni Frascotti (Milan)
      Energetic profile of Saccharomyces cerevisiae during batch cultivation on glucose

      P1.7 Alice Checcucci (Sesto Fiorentino, FI)
      Mixed nodules in Sinorhizobium meliloti - Medicago sativa symbiosis suggest the presence of a cheating behavior

      P1.8 Simona Crognale (Monterotondo, RM)
      Structure and metabolic potentialities of microbial communities in natural arsenic-polluted freshwaters

      P1.9 Francesca D'Angelo (Rome)
      Generation of synthetic cells interfacing with bacterial pathogens for innovative drug-delivery approaches

      P1.10 Luciana Di Gregorio (Monterotondo, RM)
      Biofilm diversity in cooling towers industrial systems

      P1.11 Teresa Faddetta (Palermo)
      Characterization of the microbiota from coelomic fluid of the sea urchin Paracentrotus lividus

      P1.12 Anna Grazia Ficca (Viterbo)
      Application of plant-derived protein hydrolysate Trainer stimulates the growth of Bacillus with antagonistic activity against phytopathogenic bacteria and fungi

      P1.13 Graziella Ficociello (Rome)
      Yeast-based screens to identify natural compounds for Hailey-Hailey disease

      P1.14 Luciana Giovannetti (Florence)
      Development of a high throughput approach to investigated nitrogen metabolism in Lactic Acid Bacteria 

      P1.15 Valeria Lancia (Rome)
      Anti-virulence activity of niclosamide in Pseudomonas aeruginosa isolates from cystic fibrosis patients

      P1.16 Loredana Mariniello (Naples)
      Immobilization of Aspergillus niger Cellulase on epoxy beads

      P1.17 Valentina Perri (Monterotondo, RM)
      Environmental spread of antibiotic resistance genes (ARGs) in aquatic systems with different level of microbial contamination 

      P1.18 Raffaele Porta (Naples)
      Biodegradable films and containers from bitter vetch (Vicia ervilia) seed proteins

      P1.19 Paola Quatrini (Palermo)
      Profiling microbial communities iIn hyperalkaline waters of the Kizildag ophiolite complex (Turkey)

      P1.20 Serena Rinaldo (Rome)
      Allosteric control in the synthesis and sensing of cyclic-di-GMP, a master regulator of bacterial growth and physiology

      P1.21 Maurizio Ruzzi (Viterbo)
      Microbial terroir of red and white wines from Tuscia

      P1.22 Giovanna Siracusa (Pisa)
      Recovering dredged sediments contaminated by total petroleum hydrocarbon to productive soils: the mycoremediation approach in the Bioresnova project

      P1.23 Mariarita Stirpe (Rome)
      Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells

      P1.24 Alberto Sutera (Palermo)
      Improvement of actinorhodin production yield in Streptomyces coelicolor by immobilized-cell cultivations by using PCL- and PLA-based films

      P1.25 Francesca Pittino (Milan)
      Ground Tire Rubber biodesulfurization by Gordonia desulfuricans 213E and Rhodococcus sp. AF21875

      P1.26 Daniela Uccelletti (Rome)
      Effects of Lactobacillus delbrueckii subspecies on the nematode Caenorhabdtis elegans

      P1.27 Carlo Viti (Florence)
      Response of rumen microbial ecosystem to diets integrated with chestnut or quebracho tannins in dairy ewes

      P2.1 Giuseppe Aprea (Rome)
      CrocusExpress: a coprehensive online resource for saffron transcriptomics

      P2.2 Francesco Maria Calabrese (Bari)
      Human gut microbiota across omic approaches

      P2.3 Sara Cimini (Rome)
      Protein contact networks approach applied to enzymes belonging to GH32 family

      P2.4 Federica Ciregia (Pisa)
      Treatment of pancreatic cells with palmitate alters acetylation on mitochondria

      P2.5 Daniela D'Arcangelo (Rome)
      Human melanoma and endothelial cells proliferation is inhibited by PDGFR-alpha via CXCL10/IP-10 : a multi-omics approach

      P2.6 Anna D'Erchia (Bari)
      RNA editing erofiling in Alzheimer’s disease 

      P2.7 Stefano De Benedetti (Milan)
      A multidisciplinary approach to study Sporadic Amyotrophic Lateral Sclerosis in patients with common geographical origin.

      P2.8 Guido Domingo (Varese)
      Unravelling the effects of food-related engineered nanoparticles on the GUT interactive ecosystem

      P2.9 Alfonso Esposito (Trento)
      A longitudinal population genomic study of Stenotrophomonas maltophilia in cystic fibrosis patients: expanding our knowledge about an emerging opportunistic pathogen

      P2.10 Giovanni Felici (Rome)
      Are metabolic processes affected during astrogliosis? DiVaMo, a non-standard analysis method, identifies new modifications in metabolic pathways in LPS and MCAO models of gliosis

      P2.11 Marco Gnugnoli (Milan)
      Why glutamate cannot be used as both a carbon and nitrogen source in budding yeast?

      P2.12 Serena Lacerenza (Pisa)
      Secretome profiling of malignant mesothelioma cell lines

      P2.13 Fabrizio Lombardo (Rome)
      Unraveling the olfactory repertoire of the tiger mosquito Aedes albopictus

      P2.14 Simona Martinotti (Alessandria)
      Mitochondrial proteome: characterization of the impairment due to shRNA of eIF6 using SWATH-MS analysis

      P2.15 Flavia Mascagni (Pisa)
      LTR-retrotransposons as major drivers of genome diversification across the genus Helianthus L

      P2.16 Michele Menotta (Urbino)
      Effects of dexamethasone on gene and protein expression in ataxia telangiectasia 

      P2.17 Armando Negri (Milan)
      Proteomic profiling of zirconia nanostructure-induced neuronal differentiation and neuritogenesis in different cellular models

      P2.18 Raffaele Nicastro (Milan)
      Glutamate rewires yeast metabolism and positively affects biomass yield

      P2.19 M.Eugenia Schininà (Rome)
      The ß-importome of mitotic HeLa cells

      P2.20 Gabriella Tedeschi (Milan)
      Nanorough Zirconia surfaces modulate mechanotransduction processes in human islets of Langerhans

      P2.21 Renata Tisi (Milan)
      Multi-level approach for the identification of structure-function relationships in neurofibromin type I protein

      P2.22 Maria Carmen Valoroso (Naples)
      Genome-wide analysis of DIV-like and RAD-like transcription factors in orchids

      P2.23 Alberto Vangelisti (Pisa)
      Changes in sunflower transcriptome during
      arbuscular mycorrhizal colonization

      P3.1 Danilo Cilluffo (Palermo)
      Gene expression profiling of aneuploid IMR90 cells induced by CENPE depletion

      P3.2 Francesca Degrassi (Rome)
      Identification of Hec1-microtubule targeted anticancer compounds

      P3.3 Eugenia Gilistro (Rome)
      The GTPase RAN, nuclear transport receptors and kinetochore function during mitosis  

      P3.4 Giovanna Pontarin (Padua)
      SAMHD1 regulates DNA precursors in human cells according to cell cycle progression

      P3.5 Erika Testa (Rome)
      Study of molecular mechanisms behind X-Y chromosome segregation defects in mammals

      P3.6 Annalisa Verrico (Rome)
      Importin beta regulates mitotic spindle assembly and activity via distinct molecular mechanisms

      P4.1 Barbara Banelli (Genoa)
      Up-modulation of KDM5A is a key determinant for temozolomide-resistance in glioblastoma

      P4.2 Flavia Cerrato (Caserta)
      Secondary epimutation of the Igf2/H19 Imprinting Control Region in a mouse model of the Beckwith-Wiedemann and Silver-Russell Syndromes

      P4.3 Santina Cutrupi (Orbassano, TO)
      E2 induces chromatin remodelling at the Neuroglobin-regulated genomic regions in neuronal cells

      P4.4 Francesca Di Felice (Rome)
      The in vivo reactivity of S. cerevisiae DNA topoisomerase 1 is affected by chromatin structure

      P4.5 Diletta Durano (Rome)
      Nhp6 proteins negatively contribute to transcriptional regulation of histone genes in Saccharomyces cerevisiae

      P4.6 Riccardo Gamba (Pavia)
      The epigenetic landscape of equid centromeres: a molecular approach

      P4.7 Manuela Leo (Rome)
      Epigenetic mechanisms in metabolic regulation: the involvement of HAT Gcn5 in yeast respiration

      P4.8 Laura Lori (Rome)
      Unveiling the folding mechanism of the bromodomains

      P4.9 Sara Orazi (Urbino)
      Unexpected effect of dexamethasone in ataxia telangiectasia cell lines

      P4.10 Simona Sanna (Sassari)
      Analysis of epigenetic modifications associated with Amyotrophic Lateral Sclerosis (ALS) onset and progression

      P4.11 Melissa Sorci (Rome)
      Unraveling the function of m6A modification in acute myeloid leukemia

      P4.12 Daniela Trisciuoglio (Rome)
      Chemosensitization of sarcoma cells by ITF2357 histone deacetylase inhibitor

      P5.1 Loubna Abdel Hadi (Milan)
      Sphingosine-1-phosphate in the tumor niche promotes glioblastoma malignancy

      P5.2 Italia Asteriti (Rome)
      Regulatory mechanisms of the Aurora-A/TPX2 complex: influence on chromosome stability and implications for cancer

      P5.3 Elisa Barone (Pisa)
      SOD1 and GALNT7 gene: RNAi screening on mesothelioma cell lines

      P5.4 Paola Campomenosi (Varese)
      Expression of proline dehydrogenase in non-small cell lung cancer: immunohistochemical characterization and possible regulators

      P5.5 Ferdinando Chiaradonna (Milan)
      cAMP-dependent kinase: an helper for cancer survival in stress environment

      P5.6 Angela Cirigliano (Rome)
      S.cerevisiae as a tool to select inhibitors of the deneddylating activity of the COP9 signalosome

      P5.7 Mirco Compagnone (Rome)
      Hyaluronic acid metabolism is important for the p63-dependent tumorigenesis

      P5.8 Adele Di Matteo (Rome)
      Analysis of N6L interaction with nucleophosmin and its effect on AML cell linesAnalysis of N6L interaction with nucleophosmin and its effect on AML cell lines

      P5.9 Roberta Faedda (Rome)
      Itch/βarrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumourigenesis

      P5.10 Rosa Fontana (Naples)
      The p14ARF tumor suppressor promotes cell spreading and protects cells from anoikis

      P5.11 Mimma Franceschini (Chieti)
      The nucleolar localization signal (NoLs) of fbw7γ interacts with nucleophosmin N-terminal domain

      P5.12 Maddalena Grieco (Rome)
      STAT3/ERP57/TPX2 axis and process of “androgen escape” in prostate cancer

      P5.13 Elisa Milano (Rome)
      ID4-driven cross-talk between breast cancer cells and tumor-associated macrophages

      P5.14 Elisa Paolicchi (Pisa)
      Role of the estradiol in the development of papillary thyroid carcinoma in women

      P5.15 Federica Pierucci (Florence)
      Skeletal muscle atrophy: a role for the receptor subtypes specific for sphingosine 1-phosphate 

      P5.16 Danilo Ranieri (Rome)
      Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion

      P5.17 Maria Rea (Bologna)
      Functional cooperation between p53 and MYC in cancer-associated cell competition 

      P5.18 Sara Scinicariello (Rome)
      Distinct roles of v-Jun:ATF and v-Jun:Fos dimers in skeletal muscle differentiation

      P5.19 Manuela Sollazzo (Bologna)
      MYC ectopic expression establishes a precancerous field leading to multifocal lesions in a Drosophila epithelial model

      P5.20 Clelia Tiziana Storlazzi (Bari)
      MYC-containing double minute chromosomes: origin, structure and impact upon transcriptome in acute myeloid leukemia patients

      P5.21 Doron Tolomeo (Bari)
      Chromothripsis and genomic amplifications behind a case of aggressive AML-MCR.

      P5.22 Apollonia Tullo (Bari)
      TRIM8 restores p53 tumour suppressor function through quenching of N-MYC activity and blunts tumorigenic potential and chemo-resistance in Renal Carcinoma

      P6.1 Chiara Agliassa (Turin)
      Reduction of the geomagnetic fields (GMF) delays flowering time in Arabidopsis thaliana

      P6.2 Alessandro Alboresi (Padua)
      Alternative electron transport pathways around Photosystem I in Physcomitrella patens, driving forces in terrestrialization process

      P6.3 Maurizio Badiani (Reggio Calabria)
      Profiling volatile terpenes and the expression of terpene sythase genes in conifers from Calabria forest stands

      P6.4 Cinzia Bertea (Turin)
      Changes in gene expression and metabolic responses in tomato plants (Solanum lycopersicum cv. Micro-Tom) treated with a new biostimulant

      P6.5 Andrea Carucci (Rome)
      AtCuAOδ participates in abscisic acid-induced stomatal closure in Arabidopsis

      P6.6 Valentino Casolo (Udine)
      Population traits shape the elevation effect on non-structural carbohydrates (NSC) and flavonoids of Vaccinium myrtillus stands in Alpine tundra

      P6.7 Loredana Ciarmiello (Caserta)
      Expression Analysis of  Stress-Related genes involved in the response of Durum wheat to salinity and high light

      P6.8 Fabio D'Orso (Norwich, United Kingdom)
      Metabolic engineering of the phenylpropanoid pathway in S. lycopersicum using CRISPR/Cas9 mediated genome editing

      P6.9 Alessia De Lillo (Naples)
      Subcellular localization analyses of a Hordeum vulgare P2-G6PDH isoform by transient expression of reporter fusion proteins

      P6.10 Emanuele De Paoli (Udine)
      Transgenerational responses to nitrogen deprivation in Arabidopsis thaliana 

      P6.11 Maria Concetta de Pinto (Bari)
      Cyclic AMP deficiency negatively affects thermotolerance by altering redox homeostasis

      P6.12 Francesca Degola (Parma)
      Glutamate dehydrogenase isoenzyme 3 (GDH3) of Arabidopsis thaliana is less thermostable than GDH1 and GDH2 isoenzymes

      P6.13 Sergio Esposito (Naples)
      Ultrastructural and physiological changes in barley seedlings exposed to cadmium 

      P6.14 Giuseppe Forlani (Ferrara)
      Comparison of functional properties of δ1-pyrroline-5-carboxylate reductases from plants and bacteria

      P6.15 Elide Formentin (Padua)
      Salt tolerance in an Italian rice variety is provided by rapid and specific stress responses

      P6.16 Amodio Fuggi (Caserta)
      Glutathione-Ascorbate cycle and lipid peroxidation in fruit of sweet cherry landraces of Campania region (Italy)

      P6.17 Elisabetta Giorni (Florence)
      Adaptation to metalliferous soils and nutrient use efficiency in populations of Silene paradoxa L.

      P6.18 Libero Gurrieri (Bologna)
      Pointing out the distinct features of plant and algae phosphoribulokinase

      P6.19 Vittoria Locato (Rome)
      Effects of cGMP constitutive accumulation in Arabidopsis thaliana plants challenged with avirulent pathogens

      P6.20 Giuseppe Mannino (Turin)
      Chemical characterization and standardization of bioactive boswellic acids from Boswellia (Frankincense) species by HPLC-ESI-MS/MS

      P6.21 Maria Luisa Mauro (Rome)
      Sirtuin-mediated DNA damage response by modulation of glutamate dehydrogenase activity in Arabidopsis thaliana

      P6.22 Barbara Molesini (Verona)
      Molecular insights on the role of Arabidopsis thaliana NAOD in fruit set

      P6.23 Carlo Muzi (Rome)
      Salt-tolerant related protein: a new protein involved in plant adaptation to low temperature

      P6.24 Francesca Orsini (Rome)
      Identification and quantification of flavonoids in fresh leaves and fruits of Cyclanthera pedata Scrabs (Caigua) and in their commercial food supplement preparations

      P6.25 Chiara Pagliarani (Grugliasco, TO)
      Can chemical xylem sap changes trigger grapevine isohydric and anisohydric behaviors under environmental water deficit?

      P6.26 Valeria Paradisone (Naples)
      Effect of zinc deficiency in Hordeum vulgare: are changes in morphological and physiological aspects related to alterations in nitrate uptake?

      P6.27 Michela Alfarano (Foggia)
      The existence of sirtuin activity in purified durum wheat (Triticum durum Desf.) mitochondria

      P6.28 Paola Punzo (Portici, NA)
      From an expression-based reverse genetic study to the functional characterization of two determinants of osmotic stress tolerance

      P6.29 Maria Manuela Rigano (Portici, NA)
      Key role of pectin methylesterases in controlling ascorbic acid content in tomato fruit

      P6.30 Andrea Saponaro (Milan)
      Molecular insights into the interaction between KAT1 channels and their regulatory protein 14-3-3

      P6.31 Mario Soccio (Foggia)
      First evidence of a Ca2+- induced loss of membrane potential in durum wheat mitochondria

      P6.32 Mattia Storti (Padua)
      Calcium signaling in response to abiotic stress during plant evolution

      P6.33 Patrizia Trifilo' (Messina)
      Does carbon starvation during prolonged drought prevent embolism repair pushing trees toward irreversible hydraulic failure?

      P6.34 Ivan Visentin (Grugliasco, TO)
      Strigolactones are needed for miR156 inducibility by drought in tomato

      P7.1 Angelina Cordone (Naples)
      Mycobacterium smegmatis katG mutant shows an impaired dormancy behaviour

      P7.2 Maria Letizia Di Martino (Rome)
      A leaderless mRNA supports the translation of a smaller form of  the Shigella VirF regulator 

      P7.3 Alessandra Lo Sciuto (Rome)
      Distinctive features of the LPS transport system of Pseudomonas aeruginosa

      P7.4 Martina Pasqua (Rome)
      Expression profile of efflux pumps during the intracellular life of Shigella

      P7.5 Alessandra Polissi (Milan)
      Fortifying the peptidoglycan layer to avoid cell lysis: a new role for L,D transpeptidases

      P7.6 Alessandra Romeo (Siena)
      Conjugal transfer of the conjugative and integrative element Tn5253 of Streptococcus pneumoniae is influenced by its integration site

      P8.1 Silvia Cardani (Milan)
      Newly identified PHOX2B target genes as drug targets in Congenital Central Hypoventilation Syndrome (CCHS)

      P8.2 Rosamaria Lappano (Arcavacata di Rende, CS)
      Zinc activates GPER, IGF-IR and EGFR transduction network in breast cancer cells and cancer-associated fibroblasts

      P9.1 Antonio Antoccia (Rome)
      The Nijmegen breakage syndrome protein (NBN) interacts with the heat shock protein 90 (Hsp90) through an ATM-dependent mechanism

      P9.2 Francesco Berardinelli (Rome)
      Combined exposure to the G4 ligand RHPS4 and ionizing radiation blocks the growth of glioma xenograft tumors in mice

      P9.3 Eugenia Dogliotti (Rome)
      DNA damage response in colon cancer stem cells

      P9.4 Ilaria Dutto (Pavia)
      p21CDKN1A tunes PCNA binding of NER factors thereby promoting DNA repair efficiency after UVC irradiation

      P9.5 Annapaola Franchitto (Rome)
      Role for the Werner helicase-interacting Protein 1 in response to replication stress

      P9.6 Antonella Longo (Rome)
      Dna damage response during ribosomal stress

      P9.7 Alessandra Lorenzoni (Pisa)
      Cell-cycle phase dependency of BRCA1-induced gene reversion in Saccharomyces cerevisiae

      P9.8 Daniela Muoio (Rome)
      Biological characterization of three naphthalene diimide derivative G-quadruplex ligands in U251 glioblastoma cells

      P9.9 Marco Muzi Falconi (Milan)
      TLS Polymerases are critical for a proper response to UV lesions and to prevent unscheduled DSBs in non-replicating UV-irradiated cells

      P9.10 Valentina Palermo (Rome)
      Phosphorylation of WRN by CDK1 and ATM is involved in the regulation of end-resection during DSBs repair

      P9.11 Anita Palma (Rome)
      Replication checkpoint kinase CHK2 regulates MUS81 activity in response to replication stress

      P10.1 Silvia Gasparini (Rome)
      MicroRNAs as regulators of stress-related behavior: the case of miR-135a

      P10.2 Carlo Presutti (Rome)
      RNA-Binding protein HuR and the members of miR-200 family play an unconventional role in the regulation of c-Jun mRNA

      P12.1 Stefania Astolfi (Viterbo)
      The characterization of durum wheat adaptive responses to different Fe availability highlights an optimum Fe requirement threshold

      P12.2 Catello Di Martino (Campobasso)
      Nitrogen assimilation , yield productivity and quality in mycorrhized tomato plants

      P12.3 Roberto Pinton (Udine)
      Lupinus albus (L.) plants use common mechanisms to overcome either iron (Fe) or phosphorus (P) deficiencies

      P12.4 Alessandra Rogato (Naples)
      Diatom response to variations in nitrogen availability

      P12.5 Chiara Santi (Verona)
      Action of protein hydrolysates on maize seedlings roots: a genome-wide transcriptional analysis

    • Thursday, 22 September • 13:45-15:30

      Topic 11 - Environmental and Molecular Mutagenesis

      Topic 13 - Cellular Stress, Apoptosis and Autophagy

      Topic 14 - Development, Differentiation and Aging

      Topic 15 - Metabolism and its Regulation in Health and Diseasess

      Topic 16 - Human Genetics and Genomic Diversity

      Topic 17 - Neurobiology

      Topic 18 - Immunology and Host-Pathogen Interaction

      Topic 19 - Protein Synthesis, Degradation and Homeostasis

      Topic 20 - Stem Cells, iPS, Cancer Stem Cells

      Topic 21 - Nutrition Biochemistry

      Topic 22 - Evolution

      Topic 23 - Cell Communication, Cell Adhesion and Membrane Trafficking

      Topic 24 - Plant Development and Disease

      P11.1 Tiziana Grassi (Lecce)
      Exposure to air pollution and lifestyles of children partecipating in the MAPEC_LIFE (Monitoring Air Pollution Effects on Children for supporting public health policy) study

      P11.2 Francesca Marcon (Rome)
      Toxic and genotoxic effects of repeated oral exposure to perfluorinated alkyl substances (PFAS) in C57BL/6 mice

      P11.3 Serena Montalbano (Parma)
      A biotechnological approach for the development of new antifungal compounds to protect the environment and the human health

      P11.4 Francesca Pacchierotti (Rome)
      Evaluation of synthetic amorphous silica nanoparticles toxicity on the male reproductive system in rats after sub-chronic oral exposure

      P11.5 Anna Poma (L'Aquila)
      Silica nanoparticles and ozone: an evaluation of their in vitro cytotoxicity and genotoxicity in a experimental model of indoor air

      P11.6 Sabrina Turturro (Rome)
      Characterization of telomere length and telomerase activity in iPS cells and the relationship with chromosome instability

      P11.7 Ion Udroiu (Rome)
      Effects of telomerase inhibitor Epigallocatechingallate on human glioblastoma cells

      P11.8 Marco Verani (Pisa)
      Evaluation of mutagenic/genotoxic effect of PM0.5 collected in five italian towns in two seasons: results of the MAPEC_LIFE study (LIFE12 ENV/IT/000614)

      P13.1 Alessandro Agnarelli (Pisa)
      Different responses to berberine in human cell lines 

      P13.2 Stella Donato (Naples)
      Development of an ES based system for the analysis of antioxidant or oxidant activity of natural molecules 

      P13.3 Serena Galati (Parma)
      DNA damaging agents and autophagy

      P13.4 Flavia Giamogante (Rome)
      Involment of PDIA3 in cellular response to cigarette smoke condensate

      P13.5 Luna Laera (Bari)
      Simultaneous mitochondrial retrograde pathway activation and SNF1-dependent relief of glucose repression are responsible for yeast acetic-acid induced programmed cell death evasion in raffinose.

      P13.6 Giacomo Lazzarino (Rome)
      Fusion or fission: the destiny of mitochondria in different severities of traumatic brain injury

      P13.7 Monica Marzagalli (Milan)
      Targeting cutaneous melanoma with nutraceutic compounds:
      the antitumor activity of δ-Tocotrienol

      P13.8 Silvia Masciarelli (Rome)
      Retinoic Acid sensitizes acute myeloid leukemia cells to ER stress

      P13.9 Monica Nanni (Rome)
      Role of PLCγ-mediated signaling in the crosstalk between autophagy and phagocytosis induced by FGFR2b

      P13.10 Elia Ranzato (Alessandria)
      Biological features of honeydews honeys

      P13.11 Marla Xhani (Rome)
      Cell toxicity by mitochondriotropic environmental contaminants

      P14.1 Cecilia Pucci (Pisa)
      Berberine, a natural alkaloid, affects zebrafish cardiovascular development

      P15.1 Paolo Brunotti (Rome)
      The dark side of HD-GYP phosphodiesterases revealed by the structure of Pa4781 from Pseudomonas aeruginosa displaying a bi-nuclear unselective metal binding site

      P15.2 Cristiana Carelli Alinovi (Rome)
      Role of Red Blood Cells in vascular dysfunction associated with Alzheimer ‘s disease

      P15.3 Annamaria Castello (Catania)
      The effect of Toxoplasmosis disease on plasma serotonin concentration in Sheep

      P15.4 Alida Ferlazzo (Messina)
      Physical exercise affects serotoninergic metabolism in horse leukocytes

      P15.5 Giorgio Giardina (Rome)
      X-rays induced complete Schiff-base photoreduction at the active site of human alanine:glyoxylate aminotransferase confirms that the geometrical strain of the internal aldimine is crucial for catalysis

      P15.6 Arianna Montanari (Rome)
      Yeast as a model for identification of short peptides from mitochondrial Leucyl-tRNA synthetase as a new therapeutic tool for mitochondrial tRNA diseases

      P15.7 Andrea Mozzarelli (Parma)
      Inhibition of human serine racemase by NADH and derivatives

      P15.8 Luigi Palmieri (Bari)
      Asymmetric dimethylarginine is transported across the inner mitochondrial membrane by SLC25A2

      P15.9 Francesco Papa (Bari)
      Effect of all-trans retinoic acid on post translational regulation and subcellular distribution of the oncosuppressor GRIM 19

      P15.10 Sergio Papa (Bari)
      What structural/molecular biology and spectroscopic/functional biochemistry tell us on the mechanism of energy transfer in respiratory enzymes

      P15.11 Francesca Re (Monza)
      Exploiting physiological proteins to boost the Aβ clearance from the brain: implication for Alzheimer’s disease therapy

      P15.12 Elena Sacco (Milan)
      Role of nutrient transport and redox potential in cancer metabolism of K-ras-transformed cells

      P15.13 Anna Santarsiero (Potenza)
      Role of the citrate in macrophage inflammatory response

      P15.14 Rosa Santomartino (Rome)
      Connection between hypoxic and glucose regulation of transcription in Kluyveromyces lactis

      P15.15 Barbara Tavazzi (Rome)
      Mechanisms of dysregulation of glucose metabolism following graded traumatic brain injury

      P15.16 Valentina Tortosa (Rome)
      Structural models of the human iron exporter ferroportin in the inward- and outward-open states

      P15.17 Alessandro Trentini (Ferrara)
      Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative disease

      P15.18 Mirko Zaffagnini (Bologna)
      Tuning cysteine reactivity and sulfenic acid stability by protein microenvironment in glyceraldehyde-3-phosphate dehydrogenases of Arabidopsis thaliana

      P16.1 Paolo Anagnostou (Rome)
      Overcoming the dichotomy: new insights into the genomic diversity of open and isolated european populations 

      P16.2 Stefania Brandini (Pavia)
      Mitogenome variation in Ecuador (and Peru): new clues on the first peopling of South America

      P16.3 Daniele Campa (Pisa)
      Is Infertility a matter of taste? the role of taste receptors (TAS) genes polymorphic variants  in male infertility

      P16.4 Marco Capodiferro (Pavia)
      Mitogenome insights into the genetic history of Swamp Buffalo populations

      P16.5 Fulvio Cruciani (Rome)
      Discrimination power of a forensic Y-STR multiplex (Yfiler Plus) in patrilocal populations from eastern Africa

      P16.6 Eugenia D'Atanasio (Rome)
      Human Y chromosome diversity and the peopling of the “Green Sahara” during the Holocene humid phase

      P16.7 Andrea Finocchio (Rome)
      Investigating the genetic legacy of ancient migrants to Southern Italy by Next Generation Sequencing of the Y chromosome

      P16.8 Etienne Guichard (Bologna)
      Identification of non-LTR retrotransposon insertional polymorphisms between modern and archaic human

      P16.9 Laura Lentini (Palermo)
      Identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells (CFTR deltaF508/W1282X)

      P16.10 Gemma Macchia (Bari)
      Short-time evolution and complex neocentromeres in cancer

      P16.11 Francesco Messina (Rome)
      Spatially explicit models to investigate geographic patterns in the distribution of forensic STR

      P16.12 Maria Petrosino (Rome)
      Structural and stability studies on phosphoglycerate kinase 1 natural variants

      P16.13 Alessandro Raveane (Pavia)
      A genome-wide portrait of Italy

      P16.14 Stefania Sarno (Bologna)
      An ever-changing tapestry of genes and cultures: insights into the genomic ancestry of Sicily and Southern Italy

      P16.15 Roberta Susca (Ferrara)
      Natural selection accounts for differences in dizygotic twinning rates at the worldwide scale

      P16.16 Beniamino Trombetta (Rome)
      Genetic diversity at three palindromic sequences of the human Y chromosomes

      P17.1 Valentina Brandi (Rome)
      Structural models of huntingtin ordered domains

      P17.2 Francesca Cosmi (Rome)
      Hippocampal neurons of dystrophic mdx mice are less responsive than wild type to acute corticosterone treatment in vitro

      P17.3 Matteo Formenti (Milan)
      Cellular adaptation to eustress in models of Parkinson neurodegeneration is mediated by coordinated mitochondrial responses

      P17.4 Eleonora Stronati (Rome)
      Involvement of FUS in cell cycle regulation and ALS pathogenesis

      P18.1 Martino Bolognesi (Milan)
      Chasing Burkholderia pseudomallei antigens/epitopes through a structural vaccinology approach

      P18.2 Carlo Bonchi (Rome)
      Gallium compounds targeting iron metabolism in Acinetobacter baumannii

      P18.3 Floriana Cappiello (Rome)
      Esculentin-1a(1-21)NH2 and its diastereomer: antibacterial and immunomodulating activities

      P18.4 Lorena Capriotti (Rome)
      Eosin topical treatment of psoriasis patients reduces skin secretion of inflammatory cytokines and angiogenic factors and skin leukocyte infiltration

      P18.5 Gianmarco Mangiaterra (Ancona)
      Screening of gram-negative efflux pump inhibitors from natural sources by in silico/in vitro approach

      P18.6 Elio Pizzo (Naples)
      Two new cryptic host defence peptides from human apolipoprotein E: ApoE (133-150) and ApoE (133-167)

      P18.7 Federica Runci (Rome)
      In vitro and in vivo characterization of TonB- and FeoB-dependent iron uptake systems of Acinetobacter baumannii

      P19.1 Serena Rocchio (Rome)
      RsgA from Pseudomonas aeruginosa: a structural and functional investigation

      P20.1 Ilaria Cristofaro (Rome)
      M2 receptor activation counteracts the Glioblastoma Cancer Stem Cells responses to anoxia conditions.

      P20.2 Elena Dellambra (Pomezia)
      The role of oncogenic RAS in human skin tumorigenesis  depends on clonogenic potential of the founding  keratinocytes

      P20.3 Jessica Favaro (Rome)
      Dose-dependent response of neural stem/progenitor cells to ionizing radiation

      P20.4 Carlo Guarnieri (Bologna)
      Autologous adipose tissue transplantation: regenerative potential of lipoaspirates obtained by different processing systems

      P20.5 Rossella Pistillo (Ancona)
      Immunomodulatory properties of aminiotic stem cells obtained through a newly established isolation protocol

      P20.6 Riccardo Seta (Ancona)
      Molecular and phenotypic characterization of cancer stem cells from human tumor cell lines

      P20.7 Silvia Siteni (Rome)
      Exploiting telomere and telomerase status for targeting colorectal cancer stem cells

      P20.8 Salvatore Vaiasicca (Ancona)
      Evaluation of the effect of Multistage vectors on stem cell behaviour for their potential use in Stem Cell Therapy

      P21.1 Parisa Abbasi (Milan)
      Pigmented grains as a source of immunomodulating bioactives

      P21.2 Concetta Valeria Lucia Giosafatto (Naples)
      Antioxidant properties and in vitro gastric digestion of Lathyrus sativus

      P21.3 Silvana Hrelia (Rimini)
      17β-estradiol modulates sulforaphane protection against oxidative stress in cardiomyocytes

      P21.4 Marco Malaguti (Rimini)
      Castanea Sativa Mill. bark extract exerts chemopreventive properties triggering extrinsic apoptotic pathway in Jurkat cells

      P21.5 Lorenzo Mazzoli (Florence)
      Characterization of peptide fraction from sourdoughs

      P21.6 Cecilia Prata (Bologna)
      Insulin-mimetic and antioxidant properties of the natural sweetener Stevia rebaudiana Bertoni

      P21.7 Davide Treggiari (Verona)
      Bioavailability of tomato cystine-knot miniproteins  with anti-angiogenic properties

      22.1 Andrea Benazzo (Ferrara)
      Candidate genes involved in the evolution of viviparity: a RAD sequencing experiment in the lizard Zootoca vivipara

      22.2 Giordano Botta (Rome)
      High resolution populations genomics reveals an extremely complex dynamic of early speciation in Afrotropical malaria vectors

      P23.1 Carla Cicchini (Rome)
      The RNA binding protein SYNCRIP controls microRNAs sorting in exosomes

      P23.2 Nunzia Di Maio (Naples)
      Telomerase-independent effects of dyskerin silencing in U2OS cells

      P23.3 Gian Luca Scoarughi (Palermo)
      Ultrasound stimulation affects cellular activities: examples on gene transfection, drug delivery and antibiotic production

      P24.1 Altea Alfè (Rome)
      HD-Zip II transcription factors control columella stem cell maintenance in the Arabidopsis root 

      P24.2 Alma Balestrazzi (Pavia)
      Effects of HDAC (histone deacetylase) inhibitors on the seed pre-germinative metabolism in Medicago truncatula: molecular profiles of chromatin remodeling, DNA repair and antioxidant genes

      P24.3 Daniela Bellincampi (Rome)
      Arabidopsis pectin methylesterase inhibitors participate to immunity against Botrytis cinerea

      P24.4 Luca Chiodaroli (Varese)
      Proteomic profiling of wheat roots and leaves reveals long-distance effects during infection by two rhizobacteria Burkolderia graminis and Azopsirillum brasilensis

      P24.5 Eleonora Fabri (Rome)
      Cell wall traits as resource to improve resistance to Fusarium graminearum in durum wheat

      P24.6 Simone Ferrari (Rome)
      A chimera between the EF-Tu receptor and Cf-9 confers resistance to bacterial infection

      P24.7 Matteo Gravino (Rome)
      Signaling pathways in oligogalacturonide-triggered immunity

      P24.8 Federica Locci (Rome)
      Role of an OG oxidase enzyme in Arabidopsis thaliana Immunity 

      P24.9 Simone Luti (Florence)
      A single amino acid mutation affects biological activity of cerato-platanin a non-catalytic fungal protein

      P24.10 Anca Macovei (Pavia)
      Exposure of Medicago truncatula cells to a human tyrosyl-DNA phosphodiesterase 1 (hTdp1)-specific inhibitor triggers genotoxic effects resembling the Tdp1α gene depletion

      P24.11 Giulia Mandalà (Viterbo)
      Effect of the Fusarium-mycotoxin deoxynivalenol on host innate immunity: modulation of the expression of defensins

      P24.12 Benedetta Mattei (Rome)
      Analysis of the interaction of trichodiene synthase 5 (TRI5) with natural and natural-like inhibitors of trichothecene biosynthesis

      P24.13 Nadia Napoli (Rome)
      The role of different AUXIN RESPONSE FACTORS in Arabidopsis late stamen development

      P24.14 Andrea Pagano (Pavia)
      Effects of chemical priming and physical invigouration on seed performance in Medicago truncatula: molecular profiles of the DNA damage response 

      P24.15 Stefania Pasqualini (Perugia)
      An Arabidopsis adenyl cyclase with a role in plant defense responses against a biotrophic fungus

      P24.16 Ada Ricci (Parma)
      Visualizing the relevance of bacterial blue- and red-light receptors during plant–pathogen interaction

      P24.17 Giovanna Sessa (Rome)
      The HD-Zip II transcription factor HAT3 acts via recruitment of a chromatin remodelling complex

      P24.18 Silvio Tundo (Viterbo)
      Tissue-specific expression of PvPGIP2 to improve wheat resistance against Fusarium graminearum

      P24.19 Luana Turchi (Rome)
      Role of the Arabidopsis HD-Zip II transcription factors HAT3 and ATHB4 in flower development